Guy M. Sonzo Early College High School opened on January 4, 1995 for the 1994-1995 school-year.

It was originally named Quest Early College High School, but the name was changed to Guy M. Sconzo Early College High School for the 2021-2022 school-year. 

The school serves students in 9th grade through 12th grade. 

The school colors are Green and Gold.  The school mascot is the Knights.

The school is located at 9155 Will Clayton Parkway in Humble.